Hydrogen Peroxide → HCID 20304863, compound

HRID 1732756Notes

Reaction equation

HRID 1732756 reaction equation
[CH3:1][S:2]([OH:5])(=O)=O.CS(O)(=O)=O.[Cl:11][C:12]1[CH:13]=[CH:14]C2S[C:20]3[CH:22]=[C:23]([O:28][CH3:29])[C:24]([O:26][CH3:27])=[CH:25][C:19]=3[CH2:18][CH:17]([N:30]3[CH2:35][CH2:34][N:33]([CH3:36])[CH2:32][CH2:31]3)[C:16]=2[CH:37]=1.OO.[OH-].[NH4+]>O>[Cl:11][C:12]1[CH:13]=[CH:14][C:1]2[S:2](=[O:5])[C:20]3[CH:22]=[C:23]([O:28][CH3:29])[C:24]([O:26][CH3:27])=[CH:25][C:19]=3[CH2:18][CH:17]([N:30]3[CH2:35][CH2:34][N:33]([CH3:36])[CH2:32][CH2:31]3)[C:16]=2[CH:37]=1

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 14923Ammonium HydroxideHCID 3045598Methanesulfonic acid--1-(8-chloro-2,3-dimethoxy-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-methylpiperazine (2/1)

Product 1

HCID 20304863HCID 20304863, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 8-chloro-2,3-dimethoxy-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepine dimethanesulfonate (8.5 g) (see Example 4) in water (50 ml) was treated with 30% hydrogen peroxide (16 ml) and the mixture allowed to stand for 20 hours at room temperature. Addition of ammonium hydroxide liberated the base which was extracted with benzene. The extract affords an oily residue which crystallized from a mixture of benzene-light petroleum, m.p. 178°-179° C., yield 3.70 g of the desired base.

Workup

  1. extractionwas extracted with benzene
  2. customThe extract affords an oily residue which
  3. customcrystallized from a mixture of benzene-light petroleum, m.p. 178°-179° C., yield 3.70 g of the desired base

Sources & evidence

ORD record
ord-9c83e70dd57540d79a1cb5be257eb61e
Source dataset
uspto-grants-1980_12
Patent number
US04238611

Reaction notes

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