Hydrochloric Acid → HCID 20300399, compound

HRID 1733152Notes

Reaction equation

HRID 1733152 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1Cl)([O-:3])=[O:2].[CH2:11]([CH:13]([NH2:16])[CH2:14][CH3:15])[CH3:12].Cl>O>[CH2:11]([CH:13]([NH:16][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[N+:1]([O-:3])=[O:2])[CH2:14][CH3:15])[CH3:12]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 69451-Chloro-2-nitrobenzeneHCID 120193-Pentanamine

Product 1

HCID 20300399HCID 20300399, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 158 grams of o-nitrochlorobenzene and 260 grams of 1-ethylpropylamine are refluxed together for 5 days. The solution is cooled and 500 ml. of water is added. Concentrated hydrochloric acid (10 milliliters) is added and the product separates out as an oil. The product is extracted with chloroform (2×200 milliliters), the extractions dried over MgSO4 and evaporated to yield 190 grams (91%) of product as an oil. The analytical sample is prepared by distillation of the crude oil, b.p. 1.8 mm Hg=148° C.

Workup

  1. temperatureThe solution is cooled
  2. extractionThe product is extracted with chloroform (2×200 milliliters)
  3. extractionthe extractions
  4. dry with materialdried over MgSO4
  5. customevaporated

Sources & evidence

ORD record
ord-eb0f84574c864e4398ebdad0dab1de42
Source dataset
uspto-grants-1980_12
Patent number
US04240822

Reaction notes

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