Potassium Carbonate → HCID 20299770, compound

HRID 1733495Notes

Reaction equation

HRID 1733495 reaction equation
C(=O)([O-])[O-].[K+].[K+].Cl.[CH:8]1([CH2:14][CH2:15][NH:16][CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[CH:20]=2)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.I[CH2:28][CH2:29][CH3:30]>CC(C)=O>[CH:8]1([CH2:14][CH2:15][N:16]([CH2:28][CH2:29][CH3:30])[CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[CH:20]=2)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 336431-IodopropaneHCID 20299762HCID 20299762, compound

Product 1

HCID 20299770HCID 20299770, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

48 g of potassium carbonate were added to a solution of 17.8 g of the product of Step B in 180 ml of acetone and after the addition of 17.5 ml of 1-iodopropane, the mixture was refluxed under an inert atmosphere for 41/2 hours and was filtered. The filtrate was evaporated to dryness and the residue was taken up in ether. 100 ml of 2 N sodium hydroxide solution was added to the mixture and the decanted organic phase was washed with water, dried and evaporated to dryness to obtain 19.25 g of N-(2-cyclohexylethyl)-3-methoxy-N-propyl-benzeneethanamine in the form of a yellow oil which was used as is for the next step.

Workup

  1. temperaturethe mixture was refluxed under an inert atmosphere for 41/2 hours
  2. filtrationwas filtered
  3. customThe filtrate was evaporated to dryness
  4. addition100 ml of 2 N sodium hydroxide solution was added to the mixture
  5. washthe decanted organic phase was washed with water
  6. customdried
  7. customevaporated to dryness

Sources & evidence

ORD record
ord-18fd345f5b86430ebfc38f549c7d77bf
Source dataset
uspto-grants-1980_12
Patent number
US04242355

Reaction notes

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