Dimethylformamide → HCID 19437776, compound

HRID 1734520Notes

Reaction equation

HRID 1734520 reaction equation
[CH2:1]([O:8][C:9]1[N:10]=[N:11][CH:12]=[C:13]2[C:17](Br)=[C:16]([CH3:19])[N:15]([CH2:20][C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=3)[C:14]=12)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([Li])CCC.CN(C)[CH:36]=[O:37]>CCCCCC.O1CCCC1>[CH2:1]([O:8][C:9]1[N:10]=[N:11][CH:12]=[C:13]2[C:17]([CH:36]=[O:37])=[C:16]([CH3:19])[N:15]([CH2:20][C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=3)[C:14]=12)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 6228DimethylformamideHCID 19437752HCID 19437752, compoundHCID 178418339Butyllithium

Product 1

HCID 19437776HCID 19437776, compoundYield 36%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8058HexaneSolvent

Procedure

440 mg (1.0 mmol) of 7-benzyloxy-3-bromo-1-(4-methoxybenzyl)-2-methylpyrrolo[2,3-d]pyridazine, 735 μl (1.2 mmol) of a 15% strength solution of n-butyllithium in hexane and 160 μl (1.2 mmol) of dimethylformamide are reacted in 25 ml of tetrahydrofuran as described for Example 2a. Yield: 36%, m.p.: 139°-145° C.

Sources & evidence

ORD record
ord-2bf60b6502d241cd99c65445b388fba8
Source dataset
uspto-grants-1996_07
Patent number
US05534515

Reaction notes

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