Water → HCID 19068935, compound

HRID 1735117Notes

Reaction equation

HRID 1735117 reaction equation
[SH:1][CH2:2][C:3]([O:5][CH3:6])=[O:4].[C:7]([C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]([CH3:19])[C:11]=1Cl)(=O)[CH3:8].C([O-])([O-])=O.[K+].[K+].O>CO>[CH3:8][C:7]1[C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]([CH3:19])[C:11]=2[S:1][C:2]=1[C:3]([O:5][CH3:6])=[O:4]

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 16907Methyl ThioglycolateHCID 8203443-acetyl-2-chloro-1-methylindole

Product 1

HCID 19068935HCID 19068935, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

450 μl of methyl 2-mercaptoacetate was added to a slurry of 870 mg of (76) and 1.2 g of K2CO3 in 10 ml of MeOH. The reaction was stirred overnight. 30 ml of water was added, stirring continued for 1 hour, and the product filtered off giving 160 mg of product. Recrystallization from MeOH gave 30 mg of (77). M.p. 165.5°-166.8° C.

Workup

  1. stirringstirring
  2. waitcontinued for 1 hour
  3. filtrationthe product filtered off

Sources & evidence

ORD record
ord-31a2b7d979fc4a83babe98c9a368a9d4
Source dataset
uspto-grants-1996_07
Patent number
US05536721

Reaction notes

Loading…