Water → HCID 19068938, compound

HRID 1735121Notes

Reaction equation

HRID 1735121 reaction equation
[SH:1][CH2:2][C:3]([O:5][CH3:6])=[O:4].[C:7]([C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]([CH2:19][O:20][CH2:21][CH2:22][O:23][CH3:24])[C:11]=1Cl)(=O)[CH3:8].C([O-])([O-])=O.[K+].[K+].O>CO>[CH3:24][O:23][CH2:22][CH2:21][O:20][CH2:19][N:12]1[C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:10]2[C:7]([CH3:8])=[C:2]([C:3]([O:5][CH3:6])=[O:4])[S:1][C:11]1=2

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 16907Methyl ThioglycolateHCID 19068948HCID 19068948, compound

Product 1

HCID 19068938HCID 19068938, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

400 μl of methyl 2-mercaptoacetate was added to a slurry of 1050 mg of (80) and 1.1 g of K2CO3 in 10 ml of MeOH, and left with stirring for 48 hours. 20 ml of water was added, and the precipitate filtered off and dried. This material was thoroughly washed with pentane, filtered, dried, and recrystallized from EtOH giving 230 mg of (81) as a white powder. M.p. 85.4°-86° C.

Workup

  1. waitleft
  2. filtrationthe precipitate filtered off
  3. customdried
  4. washThis material was thoroughly washed with pentane
  5. filtrationfiltered
  6. customdried
  7. customrecrystallized from EtOH giving 230 mg of (81) as a white powder

Sources & evidence

ORD record
ord-f056c2fb395e4b6283d4abbfb15f5e5c
Source dataset
uspto-grants-1996_07
Patent number
US05536721

Reaction notes

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