反应详情

To a solution of 1.0 g (3.21 mmol) of the intermediate obtained in Step B in 3.0 ml of dichloromethane was added 0.945 ml (6.74 mmol) of triethylamine and 50 mg of DMAP and finally 0.501 ml (3.53 mmol) of trifluroacetic acid anhydride. The reaction mixture was stirred for 3 hours and then diluted with 20 ml of dichloromethane. The solution was washed with water, dried over magnesium sulfate, and concentrated. Purification by flash chromatography (silica gel, hexane/ethyl acetate 2:1) gave 568 mg(1.91 mmol).

1. washThe solution was washed with water
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated
4. customPurification by flash chromatography (silica gel, hexane/ethyl acetate 2:1)
5. customgave 568 mg(1.91 mmol)