Triphosgene → HCID 19076265, compound

HRID 1735943Notes

Reaction equation

HRID 1735943 reaction equation
[NH2:1][N:2]1[CH:10]=[C:8]([CH3:9])[C:6](=[O:7])[NH:5][C:3]1=[O:4].[Cl:11][C:12](Cl)([O:14]C(=O)OC(Cl)(Cl)Cl)Cl>O1CCCC1>[Cl:11][C:12]([NH:1][N:2]1[CH:10]=[C:8]([CH3:9])[C:6](=[O:7])[NH:5][C:3]1=[O:4])=[O:14]

Participants

4

Reactant 2

HCID 94429TriphosgeneHCID 118191591-Amino thymine

Product 1

HCID 19076265HCID 19076265, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
0 °C

Procedure

1-Amino thymine (7, 12.5 g, 0.1 mol) is dissolved in tetrahydrofuran (500 mL) and the solution is cooled to 0° C. and a 2M solution of triphosgene in THF (150 mL) is added and the reaction is stirred for 4 hours. The solution is evaporated to a solid, which is used as is in the next reaction.

Workup

  1. customThe solution is evaporated to a solid, which
  2. customas is in the next reaction

Sources & evidence

ORD record
ord-83ba5ceef3a84098b64a3d73fb7698e3
Source dataset
uspto-grants-1996_07
Patent number
US05539082

Reaction notes

Loading…