Hydrochloric Acid → 2-Chloro-1-(pyridin-3-yl)ethan-1-one--hydrogen chloride (1/1)

To a solution of 12 g (11 mL, 100 mmol) of 3-acetylpyridine in 100 mL of ethylether was added 100 mL of 1M ethereal hydrogen chloride. The resultant precipitate was filtered and 15.0 g (95.2 mmol) was collected and placed in a 500-mL round bottom flask equipped with a magnetic stir bar. To this was added 95 mL of 1M hydrogen chloride in acetic acid. After the mixture was stirred until is all the solid had dissolved, 12.7 g (95.2 mmol) of N-chlorosuccinimide (NCS) was added in one portion. The solution turned yellow and the NCS gradually dissolved. After 4 h, a white precipitate had formed. The mixture was allowed to stir for 2.5 days. It was then filtered. The solid collected was washed with 10 mL of acetic acid and 200 mL of ethylether to give 15.2 g (83%) of the title compound as a white solid: 1H NMR (200 MHz, d6 -DMSO) δ9.22 (t, 1H, J=1 Hz), 8.29 (dd, 1H, J=1.6, 5.1 Hz), 8.55 (td, 1H, J=2, 8.1 Hz), 7.82 (ddd, 1H, J=0.8, 5.1, 8.1 Hz), 5.27 (s, 2H).

1. filtrationThe resultant precipitate was filtered
2. custom15.0 g (95.2 mmol) was collected
3. customplaced in a 500-mL round bottom flask
4. customequipped with a magnetic stir bar
5. additionTo this was added 95 mL of 1M hydrogen chloride in acetic acid
6. dissolutionhad dissolved
7. customa white precipitate had formed
8. stirringto stir for 2.5 days
9. filtrationIt was then filtered
10. customThe solid collected
11. washwas washed with 10 mL of acetic acid and 200 mL of ethylether

ORD record

ord-df48d75e2e8f44f9912c23fd22c01176

Source dataset

uspto-grants-1996_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05541197