1,2,3,4-Tetrahydro-1-naphthylamine → Adenine hydrochloride

HRID 1738831Notes

Reaction equation

HRID 1738831 reaction equation
[Cl:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[NH:4][CH:5]=[N:6]2.[NH2:11]C1C2C(=CC=CC=2)CCC1>C(O)(C)C>[ClH:1].[N:10]1[C:2]([NH2:11])=[C:3]2[C:7]([N:6]=[CH:5][NH:4]2)=[N:8][CH:9]=1

Participants

4

Reactant 2

HCID 180661,2,3,4-Tetrahydro-1-naphthylamineHCID 53592776-Chloropurine

Product 1

HCID 76219Adenine hydrochlorideYield 80%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A solution of 6-chloropurine (1.546 g, 10 mM) and 1-aminotetralin(1.472 g, 10 mM) in isopropanol (60 ml) is heated to reflux for about 20 h. The resulting salt suspension is then cooled to room temperature, filtered and the residue washed with ice-cooled isopropanol to give almost pure title compound in 80% yield.

Workup

  1. temperatureto reflux for about 20 h
  2. filtrationfiltered
  3. washthe residue washed with ice-
  4. temperaturecooled isopropanol

Sources & evidence

ORD record
ord-9c346e70fb0f410aa726f22592e0b1d8
Source dataset
uspto-grants-1999_10
Patent number
US05965563

Reaction notes

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