Dichloromethane → HCID 21840022, compound
Reaction equation
O[CH2:2][CH2:3][CH:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:6](=[O:16])[CH2:5]1.C([N:36]1[CH:40]=[C:39]([CH2:41][C:42]2[CH:47]=[CH:46][C:45]([C:48]#[N:49])=[CH:44][CH:43]=2)[N:38]=[CH:37]1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.C(N(C(C)C)CC)(C)C.FC(F)(F)S(OS(C(F)(F)F)(=O)=O)(=O)=O.C(Cl)[Cl:75]>>[ClH:75].[C:48]([C:45]1[CH:44]=[CH:43][C:42]([CH2:41][C:39]2[N:38]([CH2:2][CH2:3][CH:4]3[CH2:9][CH2:8][N:7]([C:10]4[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=4)[C:6](=[O:16])[CH2:5]3)[CH:37]=[N:36][CH:40]=2)=[CH:47][CH:46]=1)#[N:49]Participants
6
Conditions
- Temperature
- -78 °C
Procedure
The product from Step F (1 eq) and the product from Example 1, Step E (1 eq) were dissolved in methylene chloride containing diisopropylethylamine , cooled to -78° C. under argon and treated with trifluoromethane sulfonic anhydride as described in Example 1, Step F. After methanolysis, the title compound was isolated by chromatography on silica gel.
Sources & evidence
- ORD record
- ord-dce2448bf81e470d9fde87f4d0315b61
- Source dataset
- uspto-grants-1999_10
- Patent number
- US05965578
Reaction notes
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