Nitrogen → HCID 178447298, compound

HRID 1739067Notes

Reaction equation

HRID 1739067 reaction equation
C[O:2][C:3](=[O:28])[C@H:4]([CH3:27])[N:5]([C:21](=[O:26])[CH2:22][CH2:23][CH2:24][CH3:25])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]#[N:20])=[CH:9][CH:8]=1.CCCCC(Cl)=O.[N:36]#[N:37].C([N:40](CC)CC)C>>[NH:36]1[C:19]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[C:10]2[CH:11]=[CH:12][C:7]([CH2:6][N:5]([C:21](=[O:26])[CH2:22][CH2:23][CH2:24][CH3:25])[C@H:4]([C:3]([OH:2])=[O:28])[CH3:27])=[CH:8][CH:9]=2)=[N:20][N:40]=[N:37]1

Participants

5

Reactant 4

HCID 947Nitrogen2×HCID 8471TriethylamineHCID 61186Valeryl chlorideHCID 53687967HCID 53687967, compound

Product 1

HCID 178447298HCID 178447298, compound

Procedure

N-valeryl-N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-alanine methyl ester starting from 1.65 g of N-[(2'-cyanobiphenyl)-methyl]-(L)-alanine methyl ester, 2.7 ml of triethylamine and 2.35 ml of n-valeryl chloride and subsequent flash chromatography (N2). (TLC: system N2) Rf : 0.62.

Sources & evidence

ORD record
ord-9b3763e6a6f64454b5550f9525ce80d6
Source dataset
uspto-grants-1999_10
Patent number
US05965592

Reaction notes

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