Dimethylformamide → HCID 9935081, compound

HRID 1740067Notes

Reaction equation

HRID 1740067 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]([OH:12])[CH:9]=[C:8]2[C:3]=1[C:4]([CH3:28])=[C:5]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:6](=[O:20])[N:7]2[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[C:29](=O)([O-])[O-].[K+].[K+].Cl[CH2:36][C:37]([NH2:39])=[O:38].C[N:41]([CH:43]=[O:44])C>>[NH2:39][C:37]([CH2:36][O:1][C:2]1[CH:11]=[C:10]([O:12][CH2:29][C:43]([NH2:41])=[O:44])[CH:9]=[C:8]2[C:3]=1[C:4]([CH3:28])=[C:5]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:6](=[O:20])[N:7]2[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:38]

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 6580ChloroacetamideHCID 11430Potassium CarbonateHCID 23500375HCID 23500375, compound

Product 1

HCID 9935081HCID 9935081, compound

Procedure

The mixture of 5,7-dihydroxy-1,3-dibenzyl-4-methyl-2(1H)-quinolinone (0.5 g), potassium carbonate (0.9 g) and 2-chloroacetamide (0.25 g) in DMF (6.5 ml) were reacted at 100° C. for two hours. The reaction mixture was treated with ice water and filtered. The product was triturated with hot ethanol. Yield: 0.32 g. Melting point 252-253° C.

Workup

  1. customwere reacted at 100° C. for two hours
  2. filtrationfiltered
  3. customThe product was triturated with hot ethanol

Sources & evidence

ORD record
ord-320161301a384873893053b6c4154ae9
Source dataset
uspto-grants-1999_10
Patent number
US05968959

Reaction notes

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