反应详情

A mixture of 25.3 g of 4-t-butyl-benzoyl chloride, 30.9 g of diethyl malonate and 500 ml of tetrahydrofuran was stirred under cooling with ice and then stirred with 5.9 g of 55% sodium hydride for another 1 hour. To the reaction solution, 200 ml of aqueous ammonium chloride was added, and the tetrahydrofuran was removed by evaporation under reduced pressure. The residue was extracted with chloroform. The extract was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 36.2 g of the title compound as a pale yellow oily substance.

1. temperatureunder cooling with ice
2. customthe tetrahydrofuran was removed by evaporation under reduced pressure
3. extractionThe residue was extracted with chloroform
4. dry with materialThe extract was dried over anhydrous sodium sulfate
5. concentrationconcentrated under reduced pressure