Methanesulfonic Acid → HCID 86754642, compound

HRID 1740407Notes

Reaction equation

HRID 1740407 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:17][CH2:16][C@H:15]([CH2:18][N:19]3[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][O:27][CH3:28])[CH2:21][CH2:20]3)[C:14]2=[O:29])=[CH:9][CH:8]=1>C(OCC)(=O)C>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:17][CH2:16][C@H:15]([CH2:18][N:19]3[CH2:20][CH2:21][N:22]([CH2:25][CH2:26][O:27][CH3:28])[CH2:23][CH2:24]3)[C:14]2=[O:29])=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 9892249MS-377

Product 1

HCID 86754642HCID 86754642, compoundYield 79.7%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A solution of 240 mg of methanesulfonic acid in 5 mL of ethyl acetate was added to a solution of 880 mg of (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 15 mL of ethyl acetate. The mixture was stirred at room temperature and cooled. The precipitated solid was filtered and dried to give 892 mg of the title compound.

Workup

  1. temperaturecooled
  2. filtrationThe precipitated solid was filtered
  3. customdried

Sources & evidence

ORD record
ord-eb2a2379b311423a993de556c5f36a35
Source dataset
uspto-grants-1999_10
Patent number
US05969138

Reaction notes

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