L-Lactic Acid → HCID 131721412, compound

HRID 1740409Notes

Reaction equation

HRID 1740409 reaction equation
[C:1]([OH:6])(=[O:5])[C@H:2]([CH3:4])[OH:3].[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:18][CH2:17][C@H:16]([CH2:19][N:20]3[CH2:25][CH2:24][N:23]([CH2:26][CH2:27][O:28][CH3:29])[CH2:22][CH2:21]3)[C:15]2=[O:30])=[CH:10][CH:9]=1>C(OCC)(=O)C>[C:1]([OH:6])(=[O:5])[C@H:2]([CH3:4])[OH:3].[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:18][CH2:17][C@H:16]([CH2:19][N:20]3[CH2:21][CH2:22][N:23]([CH2:26][CH2:27][O:28][CH3:29])[CH2:24][CH2:25]3)[C:15]2=[O:30])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 107689L-Lactic AcidHCID 9892249MS-377

Product 1

HCID 131721412HCID 131721412, compoundYield 40.7%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A mixture of 106 mg of 85% L-lactic acid aq. and 10 mL of ethyl acetate was added to a solution of 352 mg of (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 10 mL of ethyl acetate. The mixture was stirred at room temperature and then concentrated. The residue was sludged with diethyl ether and dried to give 180 mg of the title compound.

Workup

  1. concentrationconcentrated
  2. customdried

Sources & evidence

ORD record
ord-f72e2405dd194823a78308c99f505692
Source dataset
uspto-grants-1999_10
Patent number
US05969138

Reaction notes

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