Hydrochloric Acid → HCID 54103739, compound

HRID 1740607Notes

Reaction equation

HRID 1740607 reaction equation
[F:1][C:2]([F:22])([F:21])[CH2:3][O:4][C:5]1[CH:10]=[C:9]([N:11]2[CH:15]=[CH:14][N:13]=[N:12]2)[CH:8]=[CH:7][C:6]=1[CH2:16][C:17]([O:19]C)=[O:18].O.O[Li].O.Cl>C1COCC1>[F:22][C:2]([F:1])([F:21])[CH2:3][O:4][C:5]1[CH:10]=[C:9]([N:11]2[CH:15]=[CH:14][N:13]=[N:12]2)[CH:8]=[CH:7][C:6]=1[CH2:16][C:17]([OH:19])=[O:18]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 54322616HCID 54322616, compound

Product 1

HCID 54103739HCID 54103739, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of methyl 2-(2,2,2-trifluoroethoxy)-4-(1-triazolyl)phenylacetate (0.54 g, 1.7 mmol) from Step 2 above in THF (10 mL) and water (2.5 mL) was added LiOH·H2O (0.11 g, 2.6 mmol). The mixture was stirred at ambient temperature for 14 h. The solution was adjusted to pH 2 by the addition of 5 N aqueous HCl and the solvents were removed under reduced pressure to give 2-(2,2,2-trifluoroethoxy)-4-(1-triazolyl)phenylacetic acid was obtained as a gum (HPLC retention time=6.0 min (method A)).

Workup

  1. customthe solvents were removed under reduced pressure

Sources & evidence

ORD record
ord-870876274ea945a7886b9267e6fef14f
Source dataset
uspto-grants-1999_10
Patent number
US05968938

Reaction notes

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