Potassium Carbonate → HCID 21833033, compound

HRID 1740747Notes

Reaction equation

HRID 1740747 reaction equation
[CH3:1][N:2]([CH3:18])[CH2:3][CH2:4][N:5]1[C:10]2[CH:11]=[C:12]3[NH:17][CH:16]=[CH:15][C:13]3=[CH:14][C:9]=2[O:8][CH2:7][CH2:6]1.C([BH3-])#N.[Na+].C(=O)([O-])[O-].[K+].[K+]>C(O)(=O)C.O>[CH3:1][N:2]([CH3:18])[CH2:3][CH2:4][N:5]1[C:10]2[CH:11]=[C:12]3[NH:17][CH2:16][CH2:15][C:13]3=[CH:14][C:9]=2[O:8][CH2:7][CH2:6]1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 5003444Sodium cyanoborohydrideHCID 21833035HCID 21833035, compound

Product 1

HCID 21833033HCID 21833033, compoundYield 80.9%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

4-(2-Dimethylaminoethyl)-2,3,4,6-tetrahydropyrrolo[2,3-g][1,4]benzoxazine (D18, 42 mg, 0.17 mmol) was stirred in acetic acid (5 ml) as sodium cyanoborohydride (33 mg, 0.52 mmol) was added portionwise over 10 min. The mixture was stirred for 2 h, diluted with water, basified with potassium carbonate, and extracted with ethyl acetate. The extract was dried (Na2SO4) and evaporated to give the title compound (34 mg, 80%) as a green gum.

Workup

  1. additionwas added portionwise over 10 min
  2. extractionextracted with ethyl acetate
  3. dry with materialThe extract was dried (Na2SO4)
  4. customevaporated

Sources & evidence

ORD record
ord-13fed31bbf904a0ba4ec8e0dcc322b34
Source dataset
uspto-grants-1999_10
Patent number
US05972935

Reaction notes

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