Potassium Carbonate → HCID 21834499, compound

HRID 1741020Notes

Reaction equation

HRID 1741020 reaction equation
[F:1][C:2]1[C:7](/[CH:8]=[CH:9]/[C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)=[C:6]([NH:16][S:17]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=2)(=[O:19])=[O:18])[CH:5]=[CH:4][CH:3]=1.I[CH2:29][CH2:30][OH:31].C(=O)([O-])[O-].[K+].[K+]>O1CCCC1>[F:1][C:2]1[C:7](/[CH:8]=[CH:9]/[C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)=[C:6]([N:16]([CH2:29][CH2:30][OH:31])[S:17]([C:20]2[CH:21]=[CH:22][C:23]([O:26][CH3:27])=[CH:24][CH:25]=2)(=[O:19])=[O:18])[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 12225IodoethanolHCID 21834493HCID 21834493, compound

Product 1

HCID 21834499HCID 21834499, compoundYield 21.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In tetrahydrofuran was dissolved 1.92 g of the compound obtained in Example 43, followed by addition of 1.72 g of 2-iodoethanol and 0.69 g of potassium carbonate. The mixture was refluxed overnight and after-treated to give crystals. This crystal crop was recrystallized from ethanol to provide 0.46 g of the title compound,(light yellow needles). m.p. 152-153° C.

Workup

  1. temperatureThe mixture was refluxed overnight
  2. additionafter-treated
  3. customto give crystals
  4. customThis crystal crop was recrystallized from ethanol

Sources & evidence

ORD record
ord-098e64bc8ebe4eb6a84a6ab40ec79145
Source dataset
uspto-grants-1999_10
Patent number
US05972976

Reaction notes

Loading…