Hydrochloric Acid → (E)-4-[2-[2-[N-(2-Methoxyethyl)-N-[(p-methoxyphenyl)sulfonyl]amino]phenyl]ethenyl]pyridine hydrochloride

HRID 1741021Notes

Reaction equation

HRID 1741021 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2/[CH:19]=[CH:20]/[C:21]2[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=2)(=[O:11])=[O:10])=[CH:5][CH:4]=1.Br[CH2:28][CH2:29][O:30][CH3:31].[ClH:32]>>[ClH:32].[CH3:31][O:30][CH2:29][CH2:28][N:12]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1/[CH:19]=[CH:20]/[C:21]1[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=1)[S:9]([C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=1)(=[O:11])=[O:10]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 809722-Bromoethyl methyl etherHCID 6366736Hmn 154

Product 1

HCID 21834528(E)-4-[2-[2-[N-(2-Methoxyethyl)-N-[(p-methoxyphenyl)sulfonyl]amino]phenyl]ethenyl]pyridine hydrochloride

Procedure

Using 1.00 g of the compound obtained in Example 3A and 1-bromo-2-methoxyethane, the reaction and after-treatment procedure of Example 9 was otherwise carried out and the product was converted to the hydrochloride. By this procedure, 0.45 g of the title compound (amorphous) was obtained.

Workup

  1. customthe reaction

Sources & evidence

ORD record
ord-d0c4664749b346c7a3489d12d5768e85
Source dataset
uspto-grants-1999_10
Patent number
US05972976

Reaction notes

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