Hydroxyamine hydrochloride → HCID 19010520, compound

HRID 1741639Notes

Reaction equation

HRID 1741639 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([CH:11]1[CH2:17][CH:16]2[N:18]([CH3:19])[CH:13]([CH2:14][CH2:15]2)[CH2:12]1)=O.[ClH:20].[NH2:21][OH:22].C([O-])(=O)C.[NH4+]>C(O)C.O>[ClH:20].[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1/[C:9](/[CH:11]1[CH2:17][CH:16]2[N:18]([CH3:19])[CH:13]([CH2:14][CH2:15]2)[CH2:12]1)=[N:21]\[OH:22]

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517165Ammonium AcetateHCID 19007838HCID 19007838, compound

Product 1

HCID 19010520HCID 19010520, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

A mixture of (2,4-difluorophenyl)(8-methyl-8-azabicyclo[3.2.1 ]octan-3-yl)methanone (20 g), hydroxylamine hydrochloride (10.6 g) and ammonium acetate (18.7 g) was heated in 67.5 ml of refluxing ethanol-water (3.2 mixture) for 19 hours. The mixture was concentrated to approximately half of its original volume, and the precipitated solid (21.3 g) was collected.

Workup

  1. concentrationThe mixture was concentrated to approximately half of its original volume
  2. customthe precipitated solid (21.3 g) was collected

Sources & evidence

ORD record
ord-c9fc6d9f647a4103abbbefa418677815
Source dataset
uspto-grants-1994_08
Patent number
US05334599

Reaction notes

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