HCID 67820753, compound → HCID 19010462, compound

HRID 1741674Notes

Reaction equation

HRID 1741674 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[CH2:13][C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[C:20]([N+:23]([O-])=O)[CH:21]=2)[N:16]([CH2:26]/[CH:27]=[CH:28]/[C:29]2[CH:38]=[CH:37][C:36]3[C:31](=[CH:32][C:33]([Cl:39])=[CH:34][CH:35]=3)[N:30]=2)[CH:15]=1)[C:6]([O:8][CH3:9])=[O:7]>CCOC(C)=O.[Rh]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[CH2:13][C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[C:20]([NH2:23])[CH:21]=2)[N:16]([CH2:26][CH2:27][CH2:28][C:29]2[CH:38]=[CH:37][C:36]3[C:31](=[CH:32][C:33]([Cl:39])=[CH:34][CH:35]=3)[N:30]=2)[CH:15]=1)[C:6]([O:8][CH3:9])=[O:7]

Participants

4

Reactant 1

HCID 67820753HCID 67820753, compound

Product 1

HCID 19010462HCID 19010462, compound

Reagents, catalysts & solvents 2

HCID 23948RhodiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

The nitroindole from Step 4 (250 mg) was hydrogenated in the presence of 5% Rh/C at atmospheric pressure in EtOAc (25 ml). After 48 hrs, the catalyst was removed to afford the crude title compound which was immediately used in the next step.

Workup

  1. customthe catalyst was removed

Sources & evidence

ORD record
ord-46f274d41a89486a961f9f8d09aeeb04
Source dataset
uspto-grants-1994_08
Patent number
US05334597

Reaction notes

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