Cyanuric chloride → HCID 86597101, compound

HRID 1743241Notes

Reaction equation

HRID 1743241 reaction equation
[CH2:1]([C@:8]1([NH:20][C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[C:15](=[O:16])[N:14]2[C@@H:10]([S:11][CH2:12][C@H:13]2[C:17]([NH2:19])=O)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N1C(Cl)=NC(Cl)=NC=1Cl>CN(C)C=O>[CH2:1]([C@:8]1([NH:20][C:21](=[O:22])[O:23][C:24]([CH3:26])([CH3:25])[CH3:27])[C:15](=[O:16])[N:14]2[C@@H:10]([S:11][CH2:12][C@H:13]2[C:17]#[N:19])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7954Cyanuric chlorideHCID 67137526HCID 67137526, compound

Product 1

HCID 86597101HCID 86597101, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

100 mg of (3R,6R,7aS)-6-benzyl-6-tert-butoxycarbonylamino-5-oxohexahydropyrrolo[2,1-b]thiazole-3-carboxamide are dissolved in 3 ml of dimethylformamide and reacted with 28.25 mg of cyanuric chloride at room temperature. After 2 hours, the volatile constituents are stripped off in vacuo at 40° C., and the residue is purified on a column (silica gel, mobile phase: diisopropyl ether:methylene chloride=100:10).

Workup

  1. customare stripped off in vacuo at 40° C.
  2. customthe residue is purified on a column (silica gel, mobile phase: diisopropyl ether:methylene chloride=100:10)

Sources & evidence

ORD record
ord-1fe94f94d63f4101950d3c8b21e5048e
Source dataset
uspto-grants-2006_03
Patent number
US07008957B2

Reaction notes

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