Sodium hydride → HCID 22235081, compound

HRID 1743574Notes

Reaction equation

HRID 1743574 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:3]=1[CH2:4][CH:5]([C:8]#[N:9])[C:6]#[N:7].[H-].[Na+].Br[CH2:18][CH2:19][C:20]([F:23])([F:22])[F:21]>CN(C)C=O>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:3]=1[CH2:4][C:5]([CH2:18][CH2:19][C:20]([F:23])([F:22])[F:21])([C:6]#[N:7])[C:8]#[N:9]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 27251143-Bromo-1,1,1-trifluoropropaneHCID 22234966HCID 22234966, compound

Product 1

HCID 22235081HCID 22235081, compoundYield 35.9%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 0.51 g of (2-chloro-4-fluorobenzyl)malononitrile, 5 ml of N,N-dimethylformamide, 0.12 g of sodium hydride (60% in oil), and 0.34 g of 1-bromo-3,3,3-trifluoropropane, and according to the process described in the Production Example 1, there was obtained 0.21 g of 2-(2-chloro-4-fluorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (44)).

Sources & evidence

ORD record
ord-06f7fddb6add432e820971a22375922b
Source dataset
uspto-grants-2006_03
Patent number
US07011838B2

Reaction notes

Loading…