反应详情

4-Cyanophenol (30 g, 250 mmol) was mixed with K2CO3 (72.5 g, 525 mmol) and stirred for 60 minutes. 4-Bromo-1-butene (50 g, 370 mmol) was added dropwise. The reaction mixture was stirred at 60° C. overnight. The solids were filtered off and the solvents were evaporated. The residue was dissolved in DCM. and washed with 1 N NaOH. The organic layer was separated, dried (Na2SO4) and evaporated to give 37 g (58%) of the sub-title compound.

1. stirringThe reaction mixture was stirred at 60° C. overnight
2. filtrationThe solids were filtered off
3. customthe solvents were evaporated
4. dissolutionThe residue was dissolved in DCM
5. washand washed with 1 N NaOH
6. customThe organic layer was separated
7. dry with materialdried (Na2SO4)
8. customevaporated