Ethyl Acetate → HCID 178418796, compound

HRID 1744325Notes

Reaction equation

HRID 1744325 reaction equation
I[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][CH:13]=[C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[NH:16][C:15]2=[O:23])=[CH:8][CH:7]=1.[CH3:24][N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1.CCOC(C)=O>C1COCC1>[CH3:24][N:25]1[CH2:30][CH2:29][N:28]([CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([NH:12][CH:13]=[C:14]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[NH:16][C:15]3=[O:23])=[CH:8][CH:7]=2)[CH2:27][CH2:26]1

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 531671-MethylpiperazineHCID 178418721HCID 178418721, compound

Product 1

HCID 178418796HCID 178418796, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
50 °C

Procedure

A solution of 3-{[4-(3-Iodo-propoxy)-phenylamino]-methylene}-1,3-dihydro-indol-2-one (66 mg, 0.157 mmol) in 1 mL THF is treated with 1-methylpiperazine (37.2 μL, 2.2 equiv.) and the resulting reaction mixture is heated at 50° C. for 4 h. The reaction mixture is cooled to room temperature and concentrated under reduced pressure. The residue is partitioned between EtOAc and H2O. The organic layer is collected and washed with saturated aqueous NaHCO3, brine, and dried over anhydrous Na2SO4. The yellow solid residue obtained upon evaporation is broken up in 1:9 EtOAc:hexane and collected by filtration to give the named compound as a yellow solid.

Workup

  1. customthe resulting reaction mixture
  2. temperatureThe reaction mixture is cooled to room temperature
  3. concentrationconcentrated under reduced pressure
  4. customThe residue is partitioned between EtOAc and H2O
  5. customThe organic layer is collected
  6. washwashed with saturated aqueous NaHCO3, brine
  7. dry with materialdried over anhydrous Na2SO4
  8. customThe yellow solid residue obtained upon evaporation
  9. filtrationhexane and collected by filtration

Sources & evidence

ORD record
ord-bc1185707c804693af9a63c6d7bdb341
Source dataset
uspto-grants-2006_03
Patent number
US07015220B2

Reaction notes

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