Hydrogen Peroxide → 7-Butoxy-1,8-difluorofluoren-2-ol

HRID 1744749Notes

Reaction equation

HRID 1744749 reaction equation
[CH2:1]([O:5][C:6]1[C:18]([F:19])=[C:17]2[C:9]([C:10]3[CH:11]=[CH:12][C:13](B(O)O)=[C:14]([F:20])[C:15]=3[CH2:16]2)=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4].[OH:24]O>COC(C)(C)C>[CH2:1]([O:5][C:6]1[C:18]([F:19])=[C:17]2[C:9]([C:10]3[CH:11]=[CH:12][C:13]([OH:24])=[C:14]([F:20])[C:15]=3[CH2:16]2)=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 222231157-Butoxy-1,8-difluorofluorene-2-boronic acid

Product 1

HCID 222231277-Butoxy-1,8-difluorofluoren-2-ol

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Procedure

The oxidation of 24 mmol of 7-butoxy-1,8-difluorofluorene-2-boronic acid with 22 ml of hydrogen peroxide (35 percent) in 60 ml of tert-butyl methyl ether is effected in a similar manner to the procedure described in Example 1. 7-Butoxy-1,8-difluorofluoren-2-ol is obtained.

Sources & evidence

ORD record
ord-fbe8386bd9414077907828e30b547124
Source dataset
uspto-grants-2006_03
Patent number
US07018685B2

Reaction notes

Loading…