Piperazine → HCID 21019682, compound

HRID 1744807Notes

Reaction equation

HRID 1744807 reaction equation
[CH2:1]([NH:8][C:9](=[O:32])[C:10]1[CH:15]=[CH:14][C:13]([N:16]2[C:21]3[N:22]=[C:23](S(C)(=O)=O)[N:24]=[C:25]([CH3:26])[C:20]=3[CH:19]=[CH:18][C:17]2=[O:31])=[CH:12][CH:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CCN(CC)CC.[NH:40]1[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]1>C1COCC1>[CH2:1]([NH:8][C:9](=[O:32])[C:10]1[CH:15]=[CH:14][C:13]([N:16]2[C:21]3[N:22]=[C:23]([N:40]4[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]4)[N:24]=[C:25]([CH3:26])[C:20]=3[CH:19]=[CH:18][C:17]2=[O:31])=[CH:12][CH:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 4837PiperazineHCID 8471TriethylamineHCID 22225250HCID 22225250, compound

Product 1

HCID 21019682HCID 21019682, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The resin (A3), 0.0214 mmol) was suspended in THF (1 ml) and NEt3 (14 mg, 0.14 mmol). To this mixture was added piperazine (21 mg, 0.128 mmol) and shaking continued for 18 h. The resin was washed with THF (2×1 min), DMF (3×1 min, 60° C.) and with DCM (3×1 min) at rt.

Workup

  1. washThe resin was washed with THF (2×1 min), DMF (3×1 min, 60° C.) and with DCM (3×1 min) at rt

Sources & evidence

ORD record
ord-12e99ac12b194867ad771a7f5d135a36
Source dataset
uspto-grants-2006_03
Patent number
US07019002B2

Reaction notes

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