Triethylamine → HCID 86655443, compound

HRID 1746484Notes

Reaction equation

HRID 1746484 reaction equation
Cl.[NH2:2][C@H:3]([C:14]([O:16][CH3:17])=[O:15])[CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1.C(N(CC)CC)C.[C:25](O)(=[O:34])[CH:26]=[CH:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[C:28]1([CH:27]=[CH:26][C:25]([NH:2][C@H:3]([C:14]([O:16][CH3:17])=[O:15])[CH2:4][C:5]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[NH:7][CH:6]=2)=[O:34])[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 87842-Propenoic acid, 3-phenyl-HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2734891Methyl tryptophanate hydrochloride

Product 1

HCID 86655443HCID 86655443, compoundYield 67.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 2 were carried out from methyl L-tryptophanate hydrochloride (4.0 g), triethylamine (4.8 mL), cinnamic acid (2.6 g), WSC.HCl (3.3 g), and methylene chloride (150 mL), to give the captioned compound (3.7 g, 67%) as an oily product.

Sources & evidence

ORD record
ord-229cd6d7db9c4b92bed8618ebd8885d8
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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