Triethylamine → HCID 86655470, compound

HRID 1746514Notes

Reaction equation

HRID 1746514 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:16]=[CH:15][C:7]([CH2:8][C@@H:9]([C:11]([O:13][CH3:14])=[O:12])[NH2:10])=[CH:6][CH:5]=1.C(N(CC)CC)C.[C:24](O)(=[O:33])[CH:25]=[CH:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][C@@H:9]([C:11]([O:13][CH3:14])=[O:12])[NH:10][C:24](=[O:33])[CH:25]=[CH:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:15][CH:16]=1

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 87842-Propenoic acid, 3-phenyl-HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 69612215(S)-Methyl 2-amino-3-(4-methoxyphenyl)propanoate hydrochloride

Product 1

HCID 86655470HCID 86655470, compoundYield 29%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 2 were carried out from the compound obtained in Example 33 (2.5 g), triethylamine (3.1 mL), cinnamic acid (1.7 g), WSC.HCl (2.1 g), and methylene chloride (100 mL), to give the captioned compound (1.0 g, 29%) as an oily product.

Sources & evidence

ORD record
ord-9182a9f60f2c4aa19c6fb01f1c3105bf
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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