Triethylamine → HCID 67311344, compound

HRID 1746527Notes

Reaction equation

HRID 1746527 reaction equation
Cl.[NH2:2][C@H:3]([C:8]([O:10][CH3:11])=[O:9])[CH2:4][CH2:5][S:6][CH3:7].C(N(CC)CC)C.[F:19][C:20]1[CH:30]=[CH:29][CH:28]=[CH:27][C:21]=1[CH:22]=[CH:23][C:24](O)=[O:25].CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[F:19][C:20]1[CH:30]=[CH:29][CH:28]=[CH:27][C:21]=1[CH:22]=[CH:23][C:24]([NH:2][C@H:3]([C:8]([O:10][CH3:11])=[O:9])[CH2:4][CH2:5][S:6][CH3:7])=[O:25]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 679773-(2-Fluorophenyl)prop-2-enoic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 11435579L-Methionine, methyl ester, hydrochloride

Product 1

HCID 67311344HCID 67311344, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 2 were carried out from methyl L-methioninate hydrochloride (2.5 g), triethylamine (2.1 mL), 2-fluorocinnamic acid (2.5 g), WSC.HCl (2.9 g, 15.0 mmol), and methylene chloride (80 mL), to give the captioned compound (3.7 g, 95%) as an oily product.

Sources & evidence

ORD record
ord-45f39a3c6da44bdface52d299ff45384
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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