Triethylamine → HCID 67130477, compound

HRID 1746601Notes

Reaction equation

HRID 1746601 reaction equation
Cl.[CH:2]([N:5]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:7]([CH2:8][C@@H:9]([C:11]([O:13][CH3:14])=[O:12])[NH2:10])=[CH:6]1)([CH3:4])[CH3:3].C(N(CC)CC)C.[F:28][C:29]1[CH:39]=[CH:38][CH:37]=[CH:36][C:30]=1[CH:31]=[CH:32][C:33](O)=[O:34].CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[F:28][C:29]1[CH:39]=[CH:38][CH:37]=[CH:36][C:30]=1[CH:31]=[CH:32][C:33]([NH:10][C@H:9]([C:11]([O:13][CH3:14])=[O:12])[CH2:8][C:7]1[C:15]2[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:5]([CH:2]([CH3:4])[CH3:3])[CH:6]=1)=[O:34]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 679773-(2-Fluorophenyl)prop-2-enoic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 67130445HCID 67130445, compound

Product 1

HCID 67130477HCID 67130477, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 146 were carried out from the compound obtained in Example 144 (0.7 g), triethylamine (0.4 mL), 2-fluorocinnamic acid (0.44 g), WSC.HCl (0.50 g), and methylene chloride (20 mL), to give the captioned compound (0.9 g, 98%) as an oily product.

Sources & evidence

ORD record
ord-3e0aba70b08043f082e253356c00cc1b
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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