Triethylamine → HCID 67311725, compound

HRID 1746602Notes

Reaction equation

HRID 1746602 reaction equation
Cl.[CH2:2]([N:6]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:8]([CH2:9][C@@H:10]([C:12]([O:14][CH3:15])=[O:13])[NH2:11])=[CH:7]1)[CH2:3][CH2:4][CH3:5].C(N(CC)CC)C.[F:29][C:30]1[CH:40]=[CH:39][CH:38]=[CH:37][C:31]=1[CH:32]=[CH:33][C:34](O)=[O:35].CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[CH2:2]([N:6]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:8]([CH2:9][C@@H:10]([C:12]([O:14][CH3:15])=[O:13])[NH:11][C:34](=[O:35])[CH:33]=[CH:32][C:31]2[CH:37]=[CH:38][CH:39]=[CH:40][C:30]=2[F:29])=[CH:7]1)[CH2:3][CH2:4][CH3:5]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 679773-(2-Fluorophenyl)prop-2-enoic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 67130572HCID 67130572, compound

Product 1

HCID 67311725HCID 67311725, compoundYield 77.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 146 were carried out from the compound obtained in Example 145 (2.0 g), triethylamine (1.0 mL), 2-fluorocinnamic acid (1.2 g), WSC.HCl (1.4 g), and methylene chloride (60 mL), to give the captioned compound (2.1 g, 77%) as an oily product.

Sources & evidence

ORD record
ord-46636c7d402c4480baa087645d87656d
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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