Hydrazine hydrate (1:1) → 6-Hydrazinonicotinic acid

HRID 1748458Notes

Reaction equation

HRID 1748458 reaction equation
O.[NH2:2][NH2:3].Cl[C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][N:6]=1>C(O)C>[NH:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][N:6]=1)[NH2:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 792226-Chloronicotinic acid

Product 1

HCID 37826176-Hydrazinonicotinic acidYield 71%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrazine monohydrate (101 g) was added to a solution of 6-chloronicotinic acid (20 g) in ethanol (20 ml) at room temperature and stirred under reflux. After completion of the reaction, the solvent was evaporated, ethanol was added and the solid was collected by filtration to give 6-hydrazinonicotinic acid (13.8 g).

Workup

  1. temperatureunder reflux
  2. customAfter completion of the reaction
  3. customthe solvent was evaporated
  4. additionethanol was added
  5. filtrationthe solid was collected by filtration

Sources & evidence

ORD record
ord-e51956cbc8cc4a818f1a40c4b2bbcf67
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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