Benzene → Methyl 2-[2-methyl-4-[3-(2-methyl-1-benzofuran-5-yl)-3-[4-(3-morpholin-4-ylprop-1-ynyl)phenyl]prop-2-enoxy]phenoxy]acetate

HRID 174895Notes

Reaction equation

HRID 174895 reaction equation
[CH2:1]([C:2]#[CH:3])[N:4]1[CH2:5][CH2:6][O:7][CH2:8][CH2:9]1.[CH3:49][CH2:50][N:51]([CH2:52][CH3:53])[CH2:54][CH3:55].[Cu:139][I:140].[I:10][c:11]1[cH:12][cH:13][c:14]([C:17](=[CH:18][CH2:19][O:20][c:21]2[cH:22][c:23]([CH3:33])[c:24]([O:25][CH2:26][C:27](=[O:28])[O:29][CH3:30])[cH:31][cH:32]2)[c:34]2[cH:35][c:36]3[c:37]([o:38][c:39]([CH3:41])[cH:40]3)[cH:42][cH:43]2)[cH:15][cH:16]1.[O:44]1[CH2:45][CH2:46][CH2:47][CH2:48]1.[cH:56]1[cH:57][cH:58][cH:59][cH:60][cH:61]1.[cH:62]1[cH:63][cH:64][c:65]([P:66]([Pd:67]([P:68]([c:69]2[cH:70][cH:71][cH:72][cH:73][cH:74]2)([c:75]2[cH:76][cH:77][cH:78][cH:79][cH:80]2)[c:81]2[cH:82][cH:83][cH:84][cH:85][cH:86]2)([P:87]([c:88]2[cH:89][cH:90][cH:91][cH:92][cH:93]2)([c:94]2[cH:95][cH:96][cH:97][cH:98][cH:99]2)[c:100]2[cH:101][cH:102][cH:103][cH:104][cH:105]2)[P:106]([c:107]2[cH:108][cH:109][cH:110][cH:111][cH:112]2)([c:113]2[cH:114][cH:115][cH:116][cH:117][cH:118]2)[c:119]2[cH:120][cH:121][cH:122][cH:123][cH:124]2)([c:125]2[cH:126][cH:127][cH:128][cH:129][cH:130]2)[c:131]2[cH:132][cH:133][cH:134][cH:135][cH:136]2)[cH:137][cH:138]1>>[CH2:1]([C:2]#[C:3][c:11]1[cH:12][cH:13][c:14]([C:17](=[CH:18][CH2:19][O:20][c:21]2[cH:22][c:23]([CH3:33])[c:24]([O:25][CH2:26][C:27](=[O:28])[O:29][CH3:30])[cH:31][cH:32]2)[c:34]2[cH:35][c:36]3[c:37]([o:38][c:39]([CH3:41])[cH:40]3)[cH:42][cH:43]2)[cH:15][cH:16]1)[N:4]1[CH2:5][CH2:6][O:7][CH2:8][CH2:9]1

Participants

8

Reactant 7

HCID 241BenzeneHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 4129414-(2-Propyn-1-yl)morpholineHCID 91225528Methyl 2-[4-[3-(4-iodophenyl)-3-(2-methyl-1-benzofuran-5-yl)prop-2-enoxy]-2-methylphenoxy]acetateHCID 178420554HCID 178420554, compound

Product 1

HCID 91321865Methyl 2-[2-methyl-4-[3-(2-methyl-1-benzofuran-5-yl)-3-[4-(3-morpholin-4-ylprop-1-ynyl)phenyl]prop-2-enoxy]phenoxy]acetate

Sources & evidence

ORD record
ord-a7b6e3bbe60441739ec7a94f99569cb9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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