Hydrochloric Acid → HCID 70981302, compound

HRID 1749076Notes

Reaction equation

HRID 1749076 reaction equation
C(O[C:6](=O)[N:7]([CH:9]([C:11](=[O:31])[NH:12][C:13]1[N:18]=[C:17]2[N:19]([CH2:23][C:24]3[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=3)[C:20](=[O:22])[NH:21][C:16]2=[CH:15][CH:14]=1)[CH3:10])C)(C)(C)C.Cl>C1COCC1.CCOC(C)=O>[ClH:30].[Cl:30][C:27]1[CH:26]=[CH:25][C:24]([CH2:23][N:19]2[C:17]3=[N:18][C:13]([NH:12][C:11](=[O:31])[CH:9]([NH:7][CH3:6])[CH3:10])=[CH:14][CH:15]=[C:16]3[NH:21][C:20]2=[O:22])=[CH:29][CH:28]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 70979845HCID 70979845, compound

Product 1

HCID 70981302HCID 70981302, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

The product from Step 4 was dissolved in THF (2 mL) and then added to a solution of saturated HCl in EtOAc. After 2 hours, the resulting precipitate was collected by filtration and washed with EtOAc to give the title compound as a white solid (30 mg). 1H NMR (400 MHz, DMSO-d6): 11.31-11.23 (1H, m), 10.87 (1H, s), 9.37 (1H, br), 8.99 (1H, br), 7.78 (1H, d), 7.47-7.35 (3H, m), 7.31 (2H, d), 5.00 (2H, s), 4.08-3.95 (1H, m), 2.57-2.53 (3H, m), 1.47 (3H, d). MS: [M+H]+ 360.

Workup

  1. filtrationthe resulting precipitate was collected by filtration
  2. washwashed with EtOAc

Sources & evidence

ORD record
ord-27ad54a737184b0da61153e0679bf5ec
Source dataset
uspto-grants-2015_10
Patent number
US09155743B2

Reaction notes

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