反应详情

To a solution of methyl 3-cyclopropylpyridine-2-carboxylate (80 mg, 0.45 mmol) in THF (2 ml) and water (2 ml) was added lithium hydroxide (55 mg, 1.36 mmol) and the reaction mixture was refluxed for 2 hours. The reaction was then acidified to pH 2 using 1M HCl (aq) and extracted with DCM (3×50 ml). The combined organics were washed with water (30 ml), brine (30 ml), dried over sodium sulfate and concentrated in vacuo to afford the title compound.

1. temperaturethe reaction mixture was refluxed for 2 hours
2. extractionextracted with DCM (3×50 ml)
3. washThe combined organics were washed with water (30 ml), brine (30 ml)
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated in vacuo