Hydrochloric Acid → HCID 118308065, compound

HRID 1750557Notes

Reaction equation

HRID 1750557 reaction equation
[CH3:1][C:2]([S:5]([NH:8][CH:9]1[CH2:17][C:12]2(OCC[O:13]2)[CH2:11][CH:10]1[N:18]([C@@H:29]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[CH3:30])[C:19](=[O:28])[O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)(=[O:7])=[O:6])([CH3:4])[CH3:3].Cl>C1COCC1>[CH3:1][C:2]([S:5]([NH:8][CH:9]1[CH2:17][C:12](=[O:13])[CH2:11][CH:10]1[N:18]([C@@H:29]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[CH3:30])[C:19](=[O:28])[O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)(=[O:6])=[O:7])([CH3:3])[CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118308191HCID 118308191, compound

Product 1

HCID 118308065HCID 118308065, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of benzyl N-[8-(2-methylpropane-2-sulfonamido)-1,4-dioxaspiro[4.4]nonan-7-yl]-N-[(1R)-1-phenylethyl]carbamate (331 mg, 0.64 mmol) in THF (1.1 ml) was added HCl (aq, 2M, 1.65 ml, 3.30 mmol) was stirred at room temperature for 18 hours. The reaction mixture was concentrated in vacuo and azeotropically distilled with toluene to afford the title compound.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. distillationazeotropically distilled with toluene

Sources & evidence

ORD record
ord-64c66cc3218b4ef68f97766f0a6bfc47
Source dataset
uspto-grants-2015_10
Patent number
US09156829B2

Reaction notes

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