Hydrochloric Acid → HCID 89654993, compound

HRID 1750889Notes

Reaction equation

HRID 1750889 reaction equation
[NH2:1][C:2]1[C:3]2[S:10][CH:9]=[C:8]([C:11]([NH:13][C:14]3[C:23]([CH3:24])=[CH:22][CH:21]=[C:20]4[C:15]=3[CH:16]=[CH:17][N:18]=[C:19]4[NH:25][C:26]3[CH:34]=[C:33]4[C:29]([CH:30]=[N:31][N:32]4C(OC(C)(C)C)=O)=[CH:28][CH:27]=3)=[O:12])[C:4]=2[N:5]=[CH:6][N:7]=1.[ClH:42]>C(OCC)(=O)C>[ClH:42].[NH:32]1[C:33]2[C:29](=[CH:28][CH:27]=[C:26]([NH:25][C:19]3[C:20]4[C:15](=[C:14]([NH:13][C:11]([C:8]5[C:4]6[N:5]=[CH:6][N:7]=[C:2]([NH2:1])[C:3]=6[S:10][CH:9]=5)=[O:12])[C:23]([CH3:24])=[CH:22][CH:21]=4)[CH:16]=[CH:17][N:18]=3)[CH:34]=2)[CH:30]=[N:31]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 117737471HCID 117737471, compound

Product 1

HCID 89654993HCID 89654993, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

tert-butyl 6-((5-(4-aminothieno[3,2-d]pyrimidine-7-carboxamido)-6-methylisoquinolin-1-yl)amino)-1H-indazol-1-carboxylate (50 mg, 0.088 mmol) obtained in Example 113 was dissolved in ethyl acetate (5 mL), and added with 4 M HCl (dioxane solution, 0.5 mL). The reaction solution was stirred for 5 hours, and then the filtrate was filtered to obtain the title compound (40 mg, 90%).

Workup

  1. filtrationthe filtrate was filtered

Sources & evidence

ORD record
ord-a6cad6b40dc34a2a810be139cd2db203
Source dataset
uspto-grants-2015_10
Patent number
US09156852B2

Reaction notes

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