4-Iodophenol → 2-(4-Iodophenoxy)-4,6-dimethoxypyrimidine

HRID 1752047Notes

Reaction equation

[I:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Cl[C:10]1[N:15]=[C:14]([O:16][CH3:17])[CH:13]=[C:12]([O:18][CH3:19])[N:11]=1.[H-].[Na+]>>[I:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:10]2[N:15]=[C:14]([O:16][CH3:17])[CH:13]=[C:12]([O:18][CH3:19])[N:11]=2)=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 108944-Iodophenol

HCID 24758Sodium hydride

HCID 51523232-Chloro-4,6-dimethoxypyrimidine

Product 1

HCID 577626232-(4-Iodophenoxy)-4,6-dimethoxypyrimidineYield 88.7%

Procedure

In the same manner as in Reference Example 8, 4-iodophenol (223 mg) and 2-chloro-4,6-dimethoxypyrimidine (192 mg) were reacted by using sodium hydride to obtain 2-(4-iodophenoxy)-4,6-dimethoxypyrimidine (322 mg).

Sources & evidence

ORD record: ord-f9b45b4b747142e9a4c0f34b1914ca0d
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09162988B2

Reaction notes

Loading…