Triethylamine → HCID 54422942, compound

To a solution of 2,4-dibromobutanoyl chloride (3.6 g, 14 mmol) in DCM (100 mL) and 2-aminoacetonitrile hydrochloride (1.3 g, 14 mmol) was added triethylamine (5.7 mL, 41 mmol) at 0° C. The mixture was stirred at ambient temperature for 24 h. To the resulting material was added methylene chloride and it was washed with water and then brine. The combined organic layers were dried over sodium sulfate, filtered, and the solvent was removed in vacuo. The resulting residue was taken up in toluene (130 mL) and at 0° C. was added sodium hydride (545 mg, 13.6 mmol, 60% in mineral oil) portion-wise over 20 minutes. The reaction was stirred at ambient temperature for 60 h. The mixture was diluted with ethyl acetate and then poured into ice water. The organic layer was separated, washed with brine, dried over sodium sulfate, and purified via flash column chromatography (ethyl acetate:hexane, 0:100 to 100:0) to provide a brown oil (730 mg, 26% yield). 1H NMR (400 MHz, CDCl3) δ 4.37-4.50 (m, 2H), 4.10-4.28 (m, 1H), 3.70 (dq, J=7.6, 2.0 Hz, 1H), 3.51-3.59 (m, 1H), 2.65-2.79 (m, J=7.0 Hz, 1H), 2.33-2.50 (m, 1H).

1. washwas washed with water
2. dry with materialThe combined organic layers were dried over sodium sulfate
3. filtrationfiltered
4. customthe solvent was removed in vacuo
5. customwas taken up in toluene (130 mL) and at 0° C.
6. stirringThe reaction was stirred at ambient temperature for 60 h
7. customThe organic layer was separated
8. washwashed with brine
9. dry with materialdried over sodium sulfate
10. custompurified via flash column chromatography (ethyl acetate:hexane, 0:100 to 100:0)

ORD record

ord-e3225c2fb99e47e68e6c945b5c037d8d

Source dataset

uspto-grants-2015_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09163003B2