Triethylamine → 2-(5-bromopyridin-2-yl)-N-(4-{[1-(propan-2-yl)-1H-pyrrolo[3,2-c]pyridin-3-yl]carbonyl}pyridin-2-yl)acetamide

HRID 1753018Notes

Reaction equation

HRID 1753018 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([OH:11])=O)=[N:6][CH:7]=1.[NH2:12][C:13]1[CH:18]=[C:17]([C:19]([C:21]2[C:25]3[CH:26]=[N:27][CH:28]=[CH:29][C:24]=3[N:23]([CH:30]([CH3:32])[CH3:31])[CH:22]=2)=[O:20])[CH:16]=[CH:15][N:14]=1.CCCP(=O)=O.C(N(CC)CC)C>C1COCC1.CCOC(C)=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([NH:12][C:13]2[CH:18]=[C:17]([C:19]([C:21]3[C:25]4[CH:26]=[N:27][CH:28]=[CH:29][C:24]=4[N:23]([CH:30]([CH3:32])[CH3:31])[CH:22]=3)=[O:20])[CH:16]=[CH:15][N:14]=2)=[O:11])=[N:6][CH:7]=1

Participants

7

Reactant 4

HCID 8471TriethylamineHCID 16167369Propylphosphoric anhydrideHCID 46238459(5-Bromopyridin-2-yl)acetic acidHCID 90093478HCID 90093478, compound

Product 1

HCID 900941972-(5-bromopyridin-2-yl)-N-(4-{[1-(propan-2-yl)-1H-pyrrolo[3,2-c]pyridin-3-yl]carbonyl}pyridin-2-yl)acetamide

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of (5-bromopyridin-2-yl)acetic acid (Preparation 83, 92 mg, 0.427 mmol) and (2-aminopyridin-4-yl)(1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)methanone (Preparation 20, 120 mg, 0.427 mmol) in THF (3 mL) was added propylphosphonic anhydride (786 uL, 1.281 mmol) and triethylamine (151 uL, 1.99 mmol) and the reaction was stirred at room temperature for 18 hours. The reaction was diluted with EtOAc, washed with saturated aqueous NaHCO3 solution, brine, dried over Na2SO4 and concentrated in vacuo. The residue was purified using preparative TLC eluting with 5% MeOH in DCM to afford the title compound.

Workup

  1. washwashed with saturated aqueous NaHCO3 solution, brine
  2. dry with materialdried over Na2SO4
  3. concentrationconcentrated in vacuo
  4. customThe residue was purified
  5. washeluting with 5% MeOH in DCM

Sources & evidence

ORD record
ord-c84108e7967a4a4bac6e3f0b51bf1e22
Source dataset
uspto-grants-2015_10
Patent number
US09163021B2

Reaction notes

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