Ammonium Chloride → 3-chloro-2-hydroxybenzamide

A mixture of 3-chloro-2-hydroxybenzoic acid (335 mg, 1.94 mmol), DIPEA (2.98 mL, 17.08 mmol), HATU (849 mg, 2.232 mmol) was dissolved in DMF (1.94 mL)/THF (7.77 mL). The reaction was stirred for 15 min, then ammonium chloride (457 mg, 8.54 mmol) was added. The reaction mixture was stirred at room temperature overnight. The volatiles were evaporated under reduced pressure. The residue was diluted with saturated 1N HCl (20 mL) and extracted with EtOAc (3×5 mL). The combined organic fractions were washed with water (30 mL), sat. NaHCO3 (20 mL), brine (20 mL), dried over MgSO4 and evaporated under reduced pressure. The resulting residue was purified by Combiflash™ chromatography (SiO2, 12 g, elution with 10-70% EtOAc/hexanes over 40 min) to afford the title compound as solid.

1. stirringThe reaction mixture was stirred at room temperature overnight
2. customThe volatiles were evaporated under reduced pressure
3. additionThe residue was diluted with saturated 1N HCl (20 mL)
4. extractionextracted with EtOAc (3×5 mL)
5. washThe combined organic fractions were washed with water (30 mL), sat. NaHCO3 (20 mL), brine (20 mL)
6. dry with materialdried over MgSO4
7. customevaporated under reduced pressure
8. customThe resulting residue was purified by Combiflash™ chromatography (SiO2, 12 g, elution with 10-70% EtOAc/hexanes over 40 min)

ORD record

ord-ba3926dbd43b47b5966e29c28ddbffbc

Source dataset

uspto-grants-2015_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09168248B2