Potassium Carbonate → HCID 86720526, compound

HRID 1755225Notes

Reaction equation

HRID 1755225 reaction equation
ClC(Cl)(Cl)[C:3]([C:5]1[NH:6][CH:7]=[CH:8][CH:9]=1)=[O:4].C([O-])([O-])=O.[K+].[K+].Br[CH2:19][C:20](=[O:24])[CH:21]([CH3:23])[CH3:22]>CC(C)=O>[CH:21]([C:20]1[O:24][C:3](=[O:4])[C:5]2=[CH:9][CH:8]=[CH:7][N:6]2[CH:19]=1)([CH3:23])[CH3:22]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 3214872-(Trichloroacetyl)pyrroleHCID 108990371-Bromo-3-methylbutan-2-one

Product 1

HCID 86720526HCID 86720526, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Conditions

Temperature
50 °C

Procedure

To a slurry of 2-(trichloroacetyl)pyrrole (5.3 g, 25 mmol) and K2CO3 (11 g, 76 mmol) in 100 mL acetone was added a solution of 1-bromo-3-methylbutan-2-one (4.5 g, 27 mmol) in 30 mL acetone. The mixture was stirred for 1 hour at 50° C. before filtering and concentrating under reduced pressure to obtain 3-isopropyl-1H-pyrrolo[2,1-c][1,4]oxazin-1-one (4.1 g, 93%), which was used in the following step without purification.

Workup

  1. filtrationbefore filtering
  2. concentrationconcentrating under reduced pressure

Sources & evidence

ORD record
ord-4763ac22a5c0404d822bfd7c491a211e
Source dataset
uspto-grants-2015_10
Patent number
US09169261B2

Reaction notes

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