Water → HCID 178520536, Verbindung

HRID 1756129Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1756129
O.C([O-])=O.[NH4+].C([N:13]1[C:17]([CH:18]([OH:34])[CH2:19][CH2:20][CH:21]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:16][N:15]=[CH:14]1)C1C=CC=CC=1>C(O)C.[Pd]>[OH:34][CH:18]([C:17]1[N:13]=[CH:14][NH:15][CH:16]=1)[CH2:19][CH2:20][CH:21]([C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Komponenten

6

Edukt 3

HCID 962WaterHCID 2723923Ammonium formateHCID 148222901-benzyl-5-(1-hydroxy-4,4-diphenylbutyl)-1H-imidazole

Produkt 1

HCID 178520536HCID 178520536, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A concentrated water solution of ammonium formate (4,0 g) is added dropwise to the boiling mixture of 1-benzyl-5-(1-hydroxy-4,4-diphenylbutyl)-1H-imidazole (4,5 g) and 10% Pd/C (0,5 g) in 50 ml of 50% ethanol. The mixture is refluxed for 2 hours. The catalyst is filtrated and the solvent is evaporated. 2M NaOH is added and the product is extracted into ethyl acetate. The ethyl acetate phase is dried and evaporated to dryness to give the product which is used in the following step b).

Aufarbeitung

  1. temperatureThe mixture is refluxed for 2 hours
  2. filtrationThe catalyst is filtrated
  3. customthe solvent is evaporated
  4. addition2M NaOH is added
  5. extractionthe product is extracted into ethyl acetate
  6. dry with materialThe ethyl acetate phase is dried
  7. customevaporated to dryness
  8. customto give the product which

Quellen und Nachweise

ORD-Eintrag
ord-f892bc4775054c30bc356191e187aa2a
Quelldatensatz
uspto-grants-1995_08
Patentnummer
US05439928

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