4-Aminopyridine → HCID 15341013, compound

HRID 1756550Notes

Reaction equation

HRID 1756550 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.CCN(CC)CC.[Cl:15][C:16]1[CH:33]=[CH:32][C:19]2[O:20][C:21]3[CH:31]=[CH:30][CH:29]=[CH:28][C:22]=3[CH2:23][N:24]([C:25](Cl)=[O:26])[C:18]=2[CH:17]=1>C(Cl)Cl>[Cl:15][C:16]1[CH:33]=[CH:32][C:19]2[O:20][C:21]3[CH:31]=[CH:30][CH:29]=[CH:28][C:22]=3[CH2:23][N:24]([C:25]([NH:1][C:2]3[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=3)=[O:26])[C:18]=2[CH:17]=1

Participants

5

Reactant 3

HCID 17274-AminopyridineHCID 8471TriethylamineHCID 149759838-chlorodibenz[b,f][1,4]oxazepin-10(11H)carbonyl chloride

Product 1

HCID 15341013HCID 15341013, compoundYield 89.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

By the method described in Example 18, 4-aminopyridine (1.3 g, 14.0 mmol) in 40 mL of CH2Cl2 with molecular sieves #5A (5 g) and Et3N (1.4 g, 15.0 mmol) was reacted with the title compound of Example 2 (4.1 g, 14.0 mmol) to produce 4.4 g of the title product after HPLC purification on silica gel.

Sources & evidence

ORD record
ord-0b605e81abff4f528cdcd1cdff8b2964
Source dataset
uspto-grants-1995_08
Patent number
US05441950

Reaction notes

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