Butyl iodide → N-(tert-Butyl)-5-isobutylthiophene-2-sulfonamide

HRID 1757083Notes

Reaction equation

HRID 1757083 reaction equation
[CH2:1]([C:5]1[S:9][C:8]([S:10]([NH:13][C:14]([CH3:17])([CH3:16])[CH3:15])(=[O:12])=[O:11])=[CH:7][CH:6]=1)[CH2:2][CH2:3]C.[CH2:18](I)CCC>CCOC(C)=O>[CH2:1]([C:5]1[S:9][C:8]([S:10]([NH:13][C:14]([CH3:15])([CH3:16])[CH3:17])(=[O:11])=[O:12])=[CH:7][CH:6]=1)[CH:2]([CH3:3])[CH3:18]

Participants

4

Reactant 2

HCID 10962Butyl iodideHCID 119939045-Butyl-N-tert-butylthiophene-2-sulfonamide

Product 1

HCID 11482758N-(tert-Butyl)-5-isobutylthiophene-2-sulfonamide

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The titled compound was prepared using the procedure described for the synthesis of 5-butyl-2-(N-t-butylaminosulfonyl)-thiophene by substituting isobutyliodide for butyliodide. Rf=0.37 (6:1 Hex/EtOAc).

Sources & evidence

ORD record
ord-93aa92d9526d484cb2a5aece2235cd0c
Source dataset
uspto-grants-1995_08
Patent number
US05444067

Reaction notes

Loading…