Trifluoroacetic acid → HCID 19389862, compound

HRID 1757084Notes

Reaction equation

HRID 1757084 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]2[N:8]([CH2:13][C:14]3[CH:19]=[CH:18][C:17]([C:20]4[CH:24]=[C:23]([CH2:25][CH2:26][CH2:27][CH3:28])[S:22][C:21]=4[S:29]([NH:32]C(C)(C)C)(=[O:31])=[O:30])=[CH:16][CH:15]=3)[C:9]([CH2:11][CH3:12])=[N:10][C:5]2=[C:4]([CH3:37])[CH:3]=1.C(O)(C(F)(F)F)=O>C1(OC)C=CC=CC=1>[CH3:1][C:2]1[N:7]=[C:6]2[N:8]([CH2:13][C:14]3[CH:19]=[CH:18][C:17]([C:20]4[CH:24]=[C:23]([CH2:25][CH2:26][CH2:27][CH3:28])[S:22][C:21]=4[S:29]([NH2:32])(=[O:31])=[O:30])=[CH:16][CH:15]=3)[C:9]([CH2:11][CH3:12])=[N:10][C:5]2=[C:4]([CH3:37])[CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 19389859HCID 19389859, compound

Product 1

HCID 19389862HCID 19389862, compound

Reagents, catalysts & solvents 1

HCID 7519AnisoleCatalyst

Procedure

To a mixture of the product of step D (215 mg, 0.40 mmol) and anisole (3 drops) was added TFA (3 mL). After standing at room temperature overnight, the solvent was removed and the residue was dissolved in EtOAc and washed with 2N Na2CO3 and brine. The organic was dried over MgSO4 and concentrated in vacuo to provide the titled compound, Rf=0.31 (20:1 CH2Cl2 /MeOH).

Workup

  1. customthe solvent was removed
  2. dissolutionthe residue was dissolved in EtOAc
  3. washwashed with 2N Na2CO3 and brine
  4. dry with materialThe organic was dried over MgSO4
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-5a3111d3f10c4509a7afb0011758a029
Source dataset
uspto-grants-1995_08
Patent number
US05444067

Reaction notes

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