Hydrochloric Acid → 3-(Pyridin-2-yl)prop-2-yn-1-ol

3-(2-Pyridyl)prop-2-yn-1-yl bromide hydrobromide used as a starting material was obtained as follows: 2-Propynyl alcohol (35 ml) was added dropwise to a stirred mixture of 2-bromopyridine (13.7 g), bis(triphenylphosphine)palladium chloride (1.54 g), triethylamine (21 ml),cuprous iodide (1.5 g) and acetonitrile (150 ml) and the mixture was stirred at ambient temperature for 30 minutes and then heated to 60° C. for 2 hours. The mixture was cooled to ambient temperature, poured into water (200 ml) and neutralised by adding dilute aqueous hydrochloric acid. The mixture was extracted with methylene chloride (2×500 ml) and the combined extracts were washed with water (500 ml), dried (MgSO4) and evaporated. The residue was purified by columnchromatography eluting with a 1:1 v/v mixture of methylene chloride and ethyl acetate to give 3-(2-pyridyl)prop-2-yn-1-yl alcohol (14 g, 70%), m.p. 78°-80° C. (recrystallised from a mixture of hexane andethyl acetate).

1. customwas obtained
2. temperatureheated to 60° C. for 2 hours
3. temperatureThe mixture was cooled to ambient temperature
4. extractionThe mixture was extracted with methylene chloride (2×500 ml)
5. washthe combined extracts were washed with water (500 ml)
6. dry with materialdried (MgSO4)
7. customevaporated
8. customThe residue was purified by columnchromatography
9. washeluting with a 1:1 v/v mixture of methylene chloride and ethyl acetate

ORD record

ord-964c7c8c43b04903998fb5a845391fe4

Source dataset

uspto-grants-1995_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05446043