反应详情

A mixture of 1.0 g (1.92 mmol) of N-[3-hydroxy-5-(octadecyloxy)phenyl]-N-(2-methoxy-2-oxoethyl)glycine methyl ester, 0.84 g (2.88 mmol) of 1-(3-bromopropoxy)-4-(methylsulfonyl) benzene, 0.53 g (3.83 mmol) of potassium carbonate and 0.3 g (1.92 mmol) of sodium iodide in 30 ml of acetone and 6 ml of DMF was stirred at refluxunder argon for 72 hours. The solvents were removed at reduced pressure andthe residual oil was purified by three recrystallizations from methylene chloride-methanol to give 1.03 g (73% yield, mp 70°-72°) of N-(2-methoxy-2-oxoethyl)-N-[3-[3-[4-(methylsulfonyl)phenoxy]propoxy]-5-(octadecyloxy)-phenyl]glycine methyl ester.

1. customfor 72 hours
2. customThe solvents were removed at reduced pressure andthe residual oil
3. customwas purified by three recrystallizations from methylene chloride-methanol